Home > Disorders of Lipid Metabolism and Molecular Nutrition. DISLIPID.

Disorders of Lipid Metabolism and Molecular Nutrition. DISLIPID.

PI: Alberto Dávalos

Email:alberto.davalos@imdea.org Phone: +34 91 727 81 00

Address: Crta. de Canto Blanco nº 8. 28049 Madrid (España)

 

Cardiometabolic diseases are the main causes of mortality in the world and excess in the diet is one of the main causes of these human diseases linked to our modern life-style. The objective is to understand how different non-coding RNAs regulate lipid metabolism during states of health and disease, developing new strategies, both pharmacological and dietetic, to modulate their function. Pharmacological or dietary modulation of the activity of non-coding RNAs that, ultimately, regulate the metabolism of lipids lead to the prevention or treatment of cardiometabolic diseases.

This unit works to generate new basic knowledge of how non-coding RNAs regulate the metabolism of lipids under physiological and pathological conditions.

To find and evaluate minor dietary components for their ability to modulate the activity of non-coding RNAs associated with the metabolism of lipids. To carry out collaborative projects with the food and / pharmaceutical industry to test and develop new dietary supplements or functional foods based on solid scientific knowledge to prevent or treat a variety of lipid metabolism disorders.

Team

PI: Dr. Alberto Dávalos

Postdoctoral researcher: Dr. María Jesús Latasa Sada

Predoctoral researcher: Judit Gil Zamorano

Laboratory Technician: Belen García Carrasco

Publications

2015

Nicod N, Parker R, Giordano E, Maestro V, Dávalos A, Visioli F. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport in Caco-2 cells. Journal of Nutrition Biochemistry. 2015; 26:165-172.
 
Daimiel L, Konstantinidou V, Mico V, Klett M, Martínez-Botas J, Dávalos A, Aranda-Gomez J, Garcia B, Fernandez-hernando C, Ordovas JM.Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system. Molecular Nutrition and Food Research. 2015; 59:552-565.
 
Giordano E, Dávalos A, Crespo MC, Tomé-Carneiro J, Gómez-Coronado D, Visioli F. Soy isoflavones in nutritionally relevant amounts have varied nutrigenomic effects on adipose tissue. Molecules 2015; 20:2310-2322.
 
Casas-Agustench P, Fernandes FS, Tavares do Carmo MG, Visioli F, Herrera E, Dávalos A. Consumption of distinct dietary lipids during early pregnancy  differentially modulates the expression of microRNAs in mothers and offspring. Plos One. 2015; 10:e0117858.
 
Ramirez de Molina A, Vargas T, Molina S, Sánchez J, Martinez-Romero J, González-Vallinas M, Martin-Hernández R, Sánchez-Martinez R, Gómez de Cedrón M, Dávalos A, Calani L, Del Rio D, González-Sarrias A, Espín JC, Tomas-Barberán FA, Reglero G. 4,4´-Di-O-methylellagic acid modulates colon cáncer cell growth through WNT16 down regulation. A promising molecule in colon cancer prevention. Journal of Pharmacology and Experimental Therapeutics. 2015; 353:433-44.
 
Gonzalo-Calvo D, Dávalos A, Montero A, García-González A, Tyshkovska I, González Medina A, Soares SMA, Martínez-Camblor P, Casas-Agustench P, Rabadán M, Díaz-Martínez A, Úbeda A, Iglesias-Gutierrez E. Circulating inflammatory miRNA signature in response to different doses of aerobic exercise. Journal Applied Physiology  2015; 119:124-34.
 
Martín-Sánchez C, Pérez-Martín JM, Jin J-S, Dávalos A, Zhang W, de la Peña G, T.E.L, Martínez-Botas J, Rodríguez-Acebes S, Suárez Y, Hazen MJ, Gómez-Coronado D, Busto R, Cheng Y-C, Lasunción MA. Disruption of the mevalonate pathway induces dNTP depletion and DNA damage. : BBA - Molecular and Cell Biology of Lipids. 2015; 1851:1240-53.
 
García-Carrasco B, Fernandez-Dacosta R, Dávalos A, Ordovás JM, Rodriguez-Casado  A. In vitro Hypolipidemic and Antioxidant Effects of Leaf and Root Extracts of Taraxacum Officinale. Medical Sciences 2015; 3:38-54.
 
Casas-Agustench P, Iglesias-Gutiérrez E, Dávalos A. Mother´s nutritional miRNA legacy: nutrition during pregnancy and its possible implications to develop cardiometabolic disease in later life. Pharmacological Research 2015; 100:322-34.
 
Nuñez-Sanchez MA, Dávalos A, González-Sarrías A, Casas-Agustench P, Visioli F, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, Martínez-Díaz F, Tomás-Barberán FA, García-Conesa MT, Espín JC. MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts. Mol Nutr Food Res. 2015; 59:1973-86.
 
Hutter N, Baena M, Sangüesa G, Dávalos A, Latasa MJ, Escolà-Gil JC, Sánchez RM, Roglans N, Alegret M, Laguna JC. Liquid fructose supplementation in LDL-R−/− mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption. International Journal of Cardiology M&E. 2015; 9:12-21.
 
Daimiel L, Ordovás JM, Dávalos A. miRNAs modified by dietary lipids in Caco-2 cells. A microarray screening. Genomic Data. 2015; 5:171-2.
 

2014

Gil-Zamorano J, Martin R, Daimiel L, Richardson K, Giordano E, Nicod N, García-Carrasco B, Soares SM, Iglesias-Gutiérrez E, Lasunción MA, Sala-Vila A, Ros E, Ordovás JM, Visioli F, Dávalos A. Docosahexaenoic Acid Modulates the Enterocyte Caco-2 Cell Expression of MicroRNAs Involved in Lipid Metabolism. J Nutr. 2014 Mar 12. 144:575-585 PubMed PMID: 24623846.
 
Parnell LD, Casas-Agustench P, Iyer LK, Ordovas JM. How Gene Networks Can Uncover Novel CVD Players. Curr Cardiovasc Risk Rep (2014) 8:372.
 
Nicod N., Chiva-Blanch G., Giordano E., Dávalos A., Parker R.S., and Visioli F. Green tea, cocoa, and red wine polyphenols moderately modulate intestinal inflammation and do not increase HDL production. Journal of Agricultural and Food Chemistry (2014) 62:2228-2232.
 
Casas-Agustench, P; Arnett D.K.; Smith C.E. ; Lai C.; Parnell L. D.; Borecki I. B.; Rich S. S.; Frazier-Wood A. C.; Allison M.; Ida Chen Y.; Taylor K. D.; Rotter J. I.; Lee Y.; Ordovás J.M. Saturated fat intake modulates the association between a genetic risk score of obesity and BMI in two US populations. Journal of the Academy of Nutrition and Dietetics. 2014 Apr 30. pii: S2212-2672(14)00357-8. doi: 10.1016/j.jand.2014.03.014.
 
Giordano E., Davalos A., Nicod N., and Visioli F. Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells. Molecular Nutrition & Food Research (2014) 58:954-962.
 
Giordano E., Dávalos A., and Visioli F. Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: a nutrigenomic study. Nutrition Metabolism and Cardiovascular Disease (2014) 24:1144-1150.
 
Zheng, JS ; Lai, CQ ; Parnell, LD ; Lee, YC ; Shen, J; Smith, CE; Casas-Agustench, P; Richardson, K; Li, D; Noel, SE; Tucker, KL; Arnett, DK; Borecki, IB ; Ordovas, JM .Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits. BMC GENOMICS  Volumen: 15. Número de artículo: 781   Fecha de publicación: SEP 11 2014.
 
Gonzalez-Castejon, M; Garcia-Carrasco, B ; Fernandez-Dacosta, R ; Davalos, A ; Rodriguez-Casado, A . Reduction of Adipogenesis and Lipid Accumulation by Taraxacum officinale (Dandelion) Extracts in 3T3L1 Adipocytes: An in vitro Study. PHYTOTHERAPY RESEARCH  Volumen: 28   Número: 5   Páginas: 745-752.
 
Daimiel-Ruiz L, Klett M, Konstantinisou V, Micó V, Aranda JF, García B, Martínez-Botas J, Dávalos A, Fernández-Hernando C, Ordovás JM. Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system. Mol Nutr Food Res. 2014 Dec 17. doi: 10.1002/mnfr.201400616.
 
Nicod N, Parker RS, Giordano E, Maestro V, Davalos A, Visioli F. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. J Nutr Biochem. 2014 Nov 12. pii: S0955-2863(14)00220-4. doi: 10.1016/j.jnutbio.2014.10.002.

 

2013

Dávalos A, Fernández-Hernando C. From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport.
Pharmacol Res. 2013 75:60-72.
 
Tomé-Carneiro J, Larrosa M, Yáñez-Gascón MJ, Dávalos A, Gil-Zamorano J, Gonzálvez M, García-Almagro FJ, Ruiz Ros JA, Tomás-Barberán FA, Espín JC, García-Conesa MT. One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. (2013) 72:69-82.
 
Giordano E, Davalos A, Nicod N, Visioli F. Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells.
Mol Nutr Food Res. 2013 Dec 18. doi: 10.1002/mnfr.201300465.
 
Olivera-Castillo L, Davalos A, Grant G, Valadez-Gonzalez N, Montero J, Barrera-Perez HA, Chim-Chi Y, Olvera-Novoa MA, Ceja-Moreno V, Acereto-Escoffie P, Rubio-Piña J, Rodriguez-Canul R. Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.
PLoS One. 2013 Nov 19;8(11):e79446. doi: 10.1371/journal.pone.0079446.