Home > Laboratory of Functional Foods. LABFUN

Laboratory of Functional Foods. LABFUN

PI: Francesco Visioli

Email:francesco.visioli@imdea.org Phone: +34 91 727 81 00

Address: Crta. de Canto Blanco nº 8. 28049 Madrid (España)


Nutritional profiles and claims offer great added value to food products and they are currently rarely constructed based on ACEs. Rather, they are based on epidemiological observations or in vitro experiments. While ACEs are in fact the standard of Pharmacology since they are the only way of providing reliable and evidence-based data, they are difficult to apply to nutrition-based environments.

In LABFUN, basic research will be carried out to gain in-depth knowledge of the etiology of cardiovascular and cardiometabolic disorders; the preventive and therapeutic role of micronutrients selected in the modulation of such diseases will be addressed by obtaining solid mechanistic evidence of their actions; studies will be conducted on animals to discover any in vivo biological activity, and security issues will also be covered; studies will be carried out on selected humans (first on healthy volunteers and then on patients) to evaluate the physiomodulatory action of micro-nutrients and their metabolism; there will be collaboration in the development and validation of functional or nutraceutical food with a high potential for entering the market.


IP: Prof. Francesco Visioli

Postdoctoral researchers: Dr. Emma Burgos Ramos , Dr. Joao Tiago Estevao Tomé Carneiro

Predoctoral researchers: Carmen Crespo

Laboratory Technician: Belen García Carrasco



Nicod N., Parker, R.S., Giordano E., Maestro V., Dàvalos A., and Visioli F. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport in Caco-2 cells.
Journal of Nutritional Biochemistry (2015) 26:165-172.



Carta, G ; Murru, E ; Ortiz, B; Giordano, E ; Belury, MA ; Quadro, L Banni, S .Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid. NUTRIENTS  Volumen: 6   Número: 3   Páginas: 1262-1272   

Nicod N., Chiva-Blanch G., Giordano E., Dávalos A., Parker R.S., and Visioli F. Green tea, cocoa, and red wine polyphenols moderately modulate intestinal inflammation and do not increase HDL production. Journal of Agricultural and Food Chemistry (2014) 62:2228-2232.

Richard D., Oszust F., Guillaume C., Millart H., Laurent-Maquin D., Brou C., Bausero P., and Visioli F. Infusion of docosahexaenoic acid protects against myocardial infarction. Prostaglandins, Leukotrienes, and Essential Fatty Acids (2014) 90:139-143.

Visioli F. and Strata A. Milk, dairy products, and their functional effects in humans: a narrative review of recent evidence. Advances in Nutrition (2014) 5:131-143.

Giordano E. and Visioli F.Long-chain omega 3 fatty acids: molecular bases of potential antioxidant actions. Prostaglandins, Leukotrienes, and Essential Fatty Acids (2014) 90:1-4.

Riso P., Vendrame S., Del Bo’, S., Martini D., Martinetti A., Seregni E., Visioli F., Parolini M., and Porrini M. Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers. International Journal of Food Sciences and Nutrition (2014) 65:106-111.

Visioli F. Rusting the pipes: ingestion of oxidized lipids and vascular disease. Vascular Pharmacology (2014) 62:47-48

Herranz Valera J., Acuña Ruiz P., Romero Valdespino B., and Visioli F. Prevalence of orthorexia nervosa among ashtanga yoga practitioners: a pilot study. Eating and Weight Disorders. 2014 May 23.

Elbir M., Amhoud A., Mbarki M., and Visioli F. Antioxidant activity of a crude preparation rich in phenolic compounds from the olive stones of two Moroccan cultivars. A preliminary study. Current Topics in Nutraceutical Research (2014) 1/2:9-11.

Giordano E., Davalos A., Nicod N., and Visioli F. Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells. Molecular Nutrition & Food Research (2014) 58:954-962

Giordano E., Dávalos A., and Visioli F. Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: a nutrigenomic study. Nutrition Metabolism and Cardiovascular Disease (2014) 24:1144-1150.

Nobbio L., Visigalli D., Radice D., Fiorina E., Solari A., Lauria G., Reilly M.M., Santoro L., Schenone A., Pareyson D.; on behalf of the CMT-TRIAAL Group. PMP22 messenger RNA levels in skin biopsies: testing the effectiveness of a Charcot-Marie-Tooth 1A biomarker.Brain (2014) 137:1614-1620.

Visioli F. The resveratrol fiasco. Pharmacol Res. 2014 Dec;90:87. doi: 10.1016/j.phrs.2014.08.003. Epub 2014 Aug 30.

Piscosquito G., Reilly M.M, Schenone A, Fabrizi G.M, Cavallaro T, Santoro L, Vita G, Quattrone A., Padua L., Gemignani F., Visioli F., Laura M., Calabrese D., Hughes R.A.C., Radice D., Solari A., and Pareyson D., for the CMT-TRIAAL & CMT-TRAUK Group.  Is overwork weakness relevant in Charcot-Marie-Tooth disease? J Neurol Neurosurg Psychiatry. 2014 Dec;85(12):1354-8. doi: 10.1136/jnnp-2014-307598. Epub 2014 Mar 21.
Nicod N, Parker RS, Giordano E, Maestro V, Davalos A, Visioli F. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. J Nutr Biochem. 2014 Nov 12. pii: S0955-2863(14)00220-4. doi: 10.1016/j.jnutbio.2014.10.002. [Epub ahead of print]

Lamaziere A, Richard D, Bausero P, Barbe U, Kefi K, Wolf C, Visioli F. Comparison of docosahexaenoic acid uptake in murine cardiomyocyte culture and tissue: Significance to physiologically relevant studies. Prostaglandins Leukot Essent Fatty Acids. 2014 Nov 24. pii: S0952-3278(14)00195-1. doi: 10.1016/j.plefa.2014.11.004. [Epub ahead of print]

Gil-Zamorano J, Martin R, Daimiel L, Richardson K, Giordano E, Nicod N, García-Carrasco B, Soares SM, Iglesias-Gutiérrez E, Lasunción MA, Sala-Vila A, Ros E, Ordovás JM, Visioli F, Dávalos A. Docosahexaenoic Acid Modulates the Enterocyte Caco-2 Cell Expression of MicroRNAs Involved in Lipid Metabolism. J Nutr. 2014 Mar 12. 144:575-585 PubMed PMID: 24623846.



Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids. Lamaziere A., Wolf C., Barbe U., Bausero P., and Visioli F. PLEFA (2013) 88: 149-154.
Toxicological evaluation of pure hydroxytyrosol. Auñon Calles D., Canut L., and Visioli F.
Food and Chemical Toxicology (2013) 55: 498-504.
Could dyslipidemic children benefit from glucomannan intake? Guardamagna O., Abello F., Cagliero P., and Visioli F.
Nutrition (2013) 29 (7-8) 1060-1065.
Hydroxytyrosol is not genotoxic in vitro. Auñon-Calles D., Giordano E., Bohnenberger S., and Visioli F.
Pharmacological Research (2013) 74:87-93.
Vitamin C and Charcot–Marie–Tooth 1A: Pharmacokinetic considerations. Visioli F., Reilly M.M., Rimoldi M., Solari A., and Pareyson D. for the CMT-TRIAAL & CMT-TRAUK Groups.
PharmaNutrition (2013) 1: 10-12.
One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Tomé-Carneiro J, Larrosa M, Yáñez-Gascón MJ, Dávalos A, Gil-Zamorano J, Gonzálvez M, García-Almagro FJ, Ruiz Ros JA, Tomás-Barberán FA, Espín JC, García-Conesa MT.
Pharmacol Res. (2013) 72:69-82.
Moderate alcohol use and health: a consensus paper. Poli A., Marangoni F., Avogaro A., Barba B., Bellentani S., Bucci M., Cambieri R., Catapano A., Costanzo S., Cricelli C., de Gaetano G., Di Castelnuovo A., Faggiano P., Fattirolli F., Fontana L., Forlani G., Frattini S., Giacco R., La Vecchia C., Lazzaretto L., Loffredo L., Lucchin L., Marelli G., Marrocco W., Minisola S., Musicco M., Novo S., Nozzoli C., Pelucchi C., Perri L., Pieralli F., Rizzoni D., Sterzi R., Vettor R., Violi F., and Visioli F. Nutrition Metabolism & Cardiovascular Disease (2013) 23:487-504.
Pharma and nutrition: crossing the Rubicon. Visioli F.
PharmaNutrition (2013) 1: 9.
Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats. Olivera-Castillo L, Davalos A, Grant G, Valadez-Gonzalez N, Montero J, Barrera-Perez HA, Chim-Chi Y, Olvera-Novoa MA, Ceja-Moreno V, Acereto-Escoffie P, Rubio-Piña J, Rodriguez-Canul R.
PLoS One. 2013 Nov 19;8(11):e79446. doi: 10.1371/journal.pone.0079446.
Xenobiotics and human health: a new view of their physiological role. Giordano E and Visioli F.
In: Interacciones dieta y xenobioticos en el siglo XXI (Ed: Varela Moreiras G.)
Nutraceuticals in the treatment of metabolic syndrome. Visioli F.
In: Nutraceuticals and Health: Review of Human Evidence (Eds: Mahabir S., and Pathak Y.), CRC Press, 2013, pp. 191-197.