Home > Production and Development of Foods for Health. PRODESALUD.

Production and Development of Foods for Health. PRODESALUD.

PI: Guillermo Reglero Rada

Email:guillermo.reglero@imdea.org Phone: +34 91 727 81 00

Address: Crta. de Canto Blanco nº 8. 28049 Madrid (España)


This line has main purpose is to connect with the food industry by establishing a bridge between molecular mechanistic research and the market by means of the development of food products for specific health use that either respond to the results generated by the basic lines of the Institute or are validated using the scientific tools of said lines.

PRODESALUD is based mainly on human resources and infrastructures external to the IMDEA Food Institute coming from the environment of the Universidad Autónoma of Madrid, with which the Institute has signed a collaboration agreement and, more specifically, within the context of the Biocampus Norte de Madrid (BUC) developed by the Universidad Autónoma and in which the IMDEA Food Institute is integrated, along with other companies in the field of biomedicine and public research centers. Researchers from the Instituto Mixto de Investigación en Ciencias de la Alimentación (Joint Institute for Research in Food Science) (UAM-CSIC), specialists in new technologies for obtaining bioactive food ingredients, will participate in the activities of this line as partners of the IMDEA Food Institute. These researchers have access to the pilot plant Novalindus, located in the aforementioned joint institute, with which the tasks of development and pilot production of the products under investigation will be carried out.




Arranz, E ; Jaime, L; de la Hazas, MCL; Vicente, G ; Reglero, G ; Santoyo, S . Supercritical sage extracts as anti-inflammatory food ingredients. Industrial Crops and Products Volume 54, March 2014, Pages 159–166. Volumen: 54. Páginas: 159-166. DOI: 10.1016/j.indcrop.2014.01.021

Santoyo, S.; Jaime, L.; Garcia-Risco, M. R.; Ruiz-Rodriguez, A.; Reglero, G. Antiviral properties of supercritical CO2 extracts from oregano and sage. International  Journal of Food Properties. 17(5)1150-1161.DOI: 10.1080/10942912.2012.700539

Casado, Victor; Reglero, G.; Torres, Carlos F. Novel and efficient solid to solid transphosphatidylation of two phenylalkanols in a biphasic GRAS medium. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. 99:14-19. DOI: 10.1016/j.molcatb.2013.10.011

Benavides, Andres M. Hurtado; Martin-Alvarez, PJ.; Vazquez, L.; Reglero, G.; Senorans, FJ; Ibanez, E. Optimization of Countercurrent Supercritical Fluid Extraction of Minor Components from Olive Oil. 10.1:78-85

Martin, D; Garcia-Serrano, A; Casado, V ; Vazquez, L; Reglero, G ; Torres, CF. Antioxidant activity of phosphatidyl derivatives of hydroxytyrosol in edible oils. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY  Volumen: 116   Número: 8   Páginas: 1035-1043   DOI: 10.1002/ejlt.201400053  Fecha de publicación: AUG 2014

Santoyo, S; Jaime, L; Garcia-Risco, MR; Lopez-Hazas, M; Reglero, G. Supercritical fluid extraction as an alternative process to obtain antiviral agents from thyme species. INDUSTRIAL CROPS AND PRODUCTS  Volumen: 52   Páginas: 475-480

Martin, D; Moran-Valero, MI; Casado, V; Reglero, G; Torres, CF. Phosphatidyl Derivative of Hydroxytyrosol. In Vitro Intestinal Digestion, Bioaccessibility, and Its Effect on Antioxidant Activity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY  Volumen: 62   Número: 40   Páginas: 9751-9759.

Martin, D; Moran-Valero, MI ; Vazquez, L; Reglero, G; Torres, CF. Comparative in vitro intestinal digestion of 1,3-diglyceride and 1-monoglyceride rich oils and their mixtures. FOOD RESEARCH INTERNATIONAL  Volumen: 64   Páginas: 603-609

González-Vallinas M, Molina S, Vicente G, Sánchez-Martínez R, Vargas T, García-Risco MR, Fornari T, Reglero G, Ramírez de Molina A. Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells. Electrophoresis. 2014Epub  Feb 25. Volumen: 35   Número: 11   Número especial: SI   Páginas: 1719-1727  

González-Vallinas M, Molina S, Vicente G, Zarza V, Martín-Hernández R, García-Risco MR, Fornari T, Reglero G, Ramírez de Molina A. Expression of MicroRNA-15b and the Glycosyltransferase GCNT3 Correlates with Antitumor Efficacy of Rosemary Diterpenes in Colon and Pancreatic Cancer. PLoS One. 2014 Jun 03; 9(6)

González-Vallinas M, Vargas T, Moreno-Rubio J, Molina S, Herranz J, Cejas P, Burgos E, Aguayo C, Custodio A, Reglero G, Feliu J, Ramírez de Molina A. Clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer. Eur J Cancer. 2014 Nov 11. pii: S0959-8049(14)01057-0. doi: 10.1016/j.ejca.2014.10.021. [Epub ahead of print]

Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells. Molina S, Moran-Valero MI, Martin D, Vázquez L, Vargas T, Torres CF, Ramirez de Molina A, Reglero G.
Chem Phys Lipids. 2013 Oct-Nov;175-176:50-6.
Study on the 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitory properties of Agaricus bisporus and extraction of bioactive fractions using pressurised solvent technologies. Gil-Ramírez A, Clavijo C, Palanisamy M, Ruiz-Rodríguez A, Navarro-Rubio M, Pérez M, Marín FR, Reglero G, Soler-Rivas C.
J Sci Food Agric. 2013 Aug 30;93(11):2789-96.
Acute and repeated dose (28 days) oral safety studies of ALIBIRD in rats. Anadón A, Martínez MA, Ares I, Castellano V, Martínez-Larrañaga MR, Corzo N, Olano A, Montilla A, Recio I, Martínez-Maqueda D, Miralles B, Fornari T, García-Risco MR, Gonzalez M, Reglero G.
J Food Prot. 2013 Jul;76(7):1226-39.
Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. González-Vallinas M, Molina S, Vicente G, de la Cueva A, Vargas T, Santoyo S, García-Risco MR, Fornari T, Reglero G, Ramírez de Molina A.
Pharmacol Res. 2013 Jun;72:61-8.
Isolation of carnosic acid from rosemary extracts using semi-preparative supercritical fluid chromatography. Vicente G, García-Risco MR, Fornari T, Reglero G.
J Chromatogr A. 2013 Apr 19;1286:208-15
Discrimination against diacylglycerol ethers in lipase-catalysed ethanolysis of shark liver oil. Fernández Ó, Vázquez L, Reglero G, Torres CF.
Food Chem. 2013 Jan 15;136(2):464-71.