Research Program. Precision Nutrition and Cancer
Computational Biology
Group leader: Dr. Enrique Carrillo de Santa Pau
Objectives: Our group aims to develop and apply integrative bioinformatic analyses to study the impact of nutritional behaviours on health and complex diseases (cancer, cardiovascular diseases,…). Bioinformatics will help us to understand the complexity of the relationships between food, genes and disease, which will allow establishing precision personalized nutrition strategies based on individual molecular background. Our research is focused on:
- The development of bioinformatic tools to integrate large genomic, epigenomic and clinical datasets
- The study of nutrition imprinting in healthy and disease status at genomic, epigenomic and transcriptomic levels
- The application of molecular knowledge acquired into precision personalized nutrition strategies
In addition, the group is active in the TransBioNet (Spanish National Bioinformatic Institute), FNS-Cloud networks and COST Action CA18131 (“Statistical and machine learning techniques in human microbiome studies”). The group members participate in innovation and education activities of EIT Food, like WeLead, AnnualFoodAgenda or MakeIT, being responsible for organizing the Madrid Summer School of the Global Food Venture Program -EIT Food for future food entrepreneurs.
Dr. Enrique Carrillo de Santa Pau
Group leader of the Computational Biology Group
Dr. Enrique Carrillo de Santa Pau, obtained his Bachelor’s degree (BSc) at the “Complutense” University (Madrid) in 2002. He completed a PhD training program (2002-2007) in Biochemistry and Molecular Biology at “Ramón y Cajal” Hospital. In 2007, he moved at Primary Health Care Service in Madrid to study Diabetes Mellitus as part of MADIABETES. He got an MsC in Bioinformatics and Computational Biology (UCM, 2009). In 2010 he joined Dr. Stunnenberg’s group at Nijmegen Centre for Molecular Life Sciences (The Netherlands) to study the role of 5hmC from a genome wide perspective. In 2011, he moved at Spanish National Cancer Research Centre (CNIO) where he was responsible for the bioinformatic analyses at the Carcinogenesis Epithelial Group lead by Dr. F.X. Real. In addition, he participated in the analysis of large-scale ‘omic’ datasets from the EU high impact initiative: “BLUEPRINT of Haematopoietic Epigenomes”, within Dr. A. Valencia’s group. From April 2018 he joined IMDEA Food Institute to lead the Computational Biology Group.
Email: enrique.carrillo@imdea.org
Phone: +34 91 727 81 00, ext. 304
Members
Laura Judith Marcos Zambrano
Postdoctoral researcher
Dr. Laura Judith Marcos Zambrano obtained her BSc in Bioanalysis at the Central University of Venezuela (UCV). She has a master degree in Cellular Signalling, she obtained her Ph.D. at the Universidad Complutense de Madrid in 2017, her doctoral investigations were carried out in Hospital Gregorio Marañon (FIB-HGM), and her work was focused in the characterization of yeasts causing fungemia: identification of species and antifungal susceptibility, molecular epidemiology, and virulence factors. She has developed her scientific career in the field of molecular microbiology, mainly in lines related to the study of the epidemiology of fungal infections, molecular studies of resistance, antifungal susceptibility, biofilm formation, diagnostic improvements, pathogenicity, and molecular characterization of strains (genotyping). She has also worked in the invertebrate model of Galleria mellonella in a pre-doctoral stay at the Universitá degli Studi di Milano (Milan, Italy). She joined the Computational Biology group at IMDEA Food in 2018, and her work is focused to lead the area of microbiome modulation by bioactive compounds with 'in silico' developments.
Email: judith.marcos@imdea.org
Phone: +34 91 727 81 00
Teresa Laguna Lobo
Postdoctoral researcher
Dr. Teresa Laguna obtained her BSc in Biochemistry in 2005 and her PhD in Immunology in 2013 at the Complutense University of Madrid. In 2015 she finished a MSc in Omics Data Analysis at the University of Vic, when she carried out a project in finding relevant signatures in the different Neuroblastoma stages in the group of Dr. Manel Esteller at IDIBELL (Hospitalet de Llobregat). After finishing her MSc, she worked there in different projects in epigenomics analysis in cancer as a postdoctoral researcher. In 2016, she started as a postdoctoral bioinformatician at the Institute of Molecular Biology in Mainz (Germany) where she participated in proteomics pipeline development and data analysis, and leaded the bioinformatic efforts in gene annotation improvement in vertebrate species by integration of proteomics and RNA-seq data. In 2019, she moved to IMDEA where she is focused in applying human epi-genome inter-variability for effective personalized nutrition strategies.
Email: teresa.laguna@imdea.org
Phone: +34 91 727 81 00
