Research Program. Precision Nutrition and Cancer

Computational Biology

Group leader: Dr. Enrique Carrillo de Santa Pau

Objectives: Our group aims to develop and apply integrative bioinformatic analyses to study the impact of nutritional behaviours on health and complex diseases (cancer, cardiovascular diseases,…). Bioinformatics will help us to understand the complexity of the relationships between food, genes and disease, which will allow establishing precision personalized nutrition strategies based on individual molecular background. Our research is focused on:

  • The development of bioinformatic tools to integrate large genomic, epigenomic and clinical datasets
  • The study of nutrition imprinting in healthy and disease status at genomic, epigenomic and transcriptomic levels
  • The application of molecular knowledge acquired into precision personalized nutrition strategies

Dr. Enrique Carrillo de Santa Pau

Group leader of the Computational Biology Group

Dr. Enrique Carrillo de Santa Pau, obtained his Bachelor’s degree (BSc) at the “Complutense” University (Madrid) in 2002. He completed a PhD training program (2002-2007) in Biochemistry and Molecular Biology at “Ramón y Cajal” Hospital. In 2007, he moved at Primary Health Care Service in Madrid to study Diabetes Mellitus as part of MADIABETES. He got an MsC in Bioinformatics and Computational Biology (UCM, 2009). In 2010 he joined Dr. Stunnenberg’s group at Nijmegen Centre for Molecular Life Sciences (The Netherlands) to study the role of 5hmC from a genome wide perspective. In 2011, he moved at Spanish National Cancer Research Centre (CNIO) where he was responsible for the bioinformatic analyses at the Carcinogenesis Epithelial Group lead by Dr. F.X. Real. In addition, he participated in the analysis of large-scale ‘omic’ datasets from the EU high impact initiative: “BLUEPRINT of Haematopoietic Epigenomes”, within Dr. A. Valencia’s group. From April 2018 he joined IMDEA Food Institute to lead the Computational Biology Group.

Email: enrique.carrillo@imdea.org 
Phone: +34 91 727 81 00, ext. 304

Members

                                  

most relevant publications
  • Isidoro Cobo; Paola Martinelli; Marta Flan-dez; Latifa Bakiri; Mingfeng Zhang; Enrique Carrillo-de-Santa-Pau; Jinping Jia; Liv Thom-mesen; Torunn Bruland; Natalia del Pozo; et al. Transcriptional regulation by NR5A2 links differentiation and inflammation in the pan-creas. Nature. 10.1038/nature25751, Nature Publishing Group, 2018. Available on-line at: <http://dx.doi.org/10.1038/nature25751>
  • Enrique Carrillo-de-Santa-Pau*; David Juan*; Vera Pancaldi; Felipe Were; Ignacio Martin-Subero; Daniel Rico; Alfonso Valencia; BLUE-PRINT Consortium. Automatic identification of  informative  regions  with  epigenomic  changes  associated  to  hematopoiesis.  Nucleic acids research. 45 - 16, pp. 9244 - 9259. Oxford University Press, 2017.*Co-First authors.
  • David Juan*; Juliane Perner*; Enrique Carrillo de Santa Pau*; Simone Marsili*; David Ochoa; Ho-Ryun Chung; Martin Vingron; Daniel Rico; Alfonso Valencia. Epigenomic co-localization and co-evolution reveal a key role for 5hmC as a communication hub in the chromatin network of ESCs. Cell reports. 14 - 5, pp. 1246 - 1257. Cell Press, 2016.*Co-First authors.
  • Vera Pancaldi; Enrique Carrillo-de-Santa-Pau; Biola Maria Javierre; David Juan; Peter Fraser; Mikhail Spivakov; Alfonso Valencia; Daniel Rico. Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity. Genome biology. 17 - 1, pp. 152 - 152. BioMed Central, 2016.
  • Marcos-Zambrano, LJ; Gómez, A; Sánchez-Carrillo, C; Bou-za, E; Muñoz, P; Escribano, P; Guinea, J. Isavuconazole is highly active inávitro against Candida species isolates but shows trailing effect. Clinical Microbiology and Infec-tion, 22, 12, 1343. e1-1343. e4, 2018, Elsevier
main research grants

Principal Investigator: Enrique Carrillo de Santa Pau
Project Title: Fórmulas terapéuticas de nutrición de precisión para el cáncer - ALIBIRD2020-CM
Date: 2019-2022
Funded by: Comunidad de Madrid (P2018/BAA-4343)

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Principal Investigator: Enrique Carrillo de Santa Pau
Project Title: Nutritional strategies and bioactive compounds to target lipid metabolism alterations in cancer: Platform of Patient derived Paired Organoids for Precision Nutrition
Date: 2019-2021
Funded by: Fundación Ramón Areces

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Principal Investigator: Enrique Carrillo de Santa Pau
Project Title: COST Action CA18131 (“Statistical and machine learning techniques in human microbiome studies”)
Date: 2018-2022
Funded by: The European Cooperation in Science and Technology (COST)

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Principal Investigator: Enrique Carrillo de Santa Pau
Project Title: BLUEPRINT – A BLUEPRINT of Haematopoietic Epigenomes
Date: 2011-2016
Funded by: 7th Framework Programme for Research and Technological Develop-ment of the European Commission
(FP7/ No282510)

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Principal Investigator: Enrique Carrillo de Santa Pau
Project Title: COST Action CA18131 (“Statistical and machine learning techniques in human microbiome studies”)
Date: 2018-2022
Funded by: The European Cooperation in Science and Technology (COST)

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Principal Investigator: Enrique Carrillo de Santa Pau
Project Title: Estudio de cohortes sobre la morbilidad cardiovascular y mortalidad de sujetos con diabetes T2 conocida y no conocida, prediabetes y normoglucemia
Date: 2015-2019
Funded by: Ministerio de Sanidad y Con-sumo. Fondo de Investigación Sanitaria (PI1500259)

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