Research Program. Precision Nutrition and Aging

Posttranscriptional Regulation of Metabolic Diseases

Group leader: Dr. Cristina Ramírez Hidalgo

Objectives: Aging is an important contributor to the etiologies of metabolic decline and related diseases, including cardiovascular disease, T2DM and neurodegenerative disorders. Metabolic diseases are characterized by the failure of regulatory genes or enzymes to effectively orchestrate specifi c pathways involved in the control of key biological processes. In addition to the classical transcriptional regulators, recent discoveries have shown the remarkable role of small non-coding RNAs (microRNAs) and RNA binding proteins (RBPs) in the posttranscriptional regulation of metabolism, and their involvement in many pathological states. Our interest in this area is to discover and characterize novel molecular mechanisms that underlie dysregulation of lipid metabolism, glucose homeostasis, and infl ammation during the development of pathologies like Alzheimer´s Disease, Diabetes and Atherosclerosis. Our group will approach these studies from a global perspective. Using a combination of genomics, in vivo models of human diseases, biochemistry, bioinformatics and molecular biology, we will investigate networks of non-coding RNAs and RBPs and their target genes to evaluate their impact on biological processes and age-related pathologies. These areas of investigation are necessary, not only because they address fundamental questions, but also because they will be of undeniable benefi t in our efforts to better understand and potentially treat ageassociated diseases.

Dr. Cristina Ramírez Hidalgo

 Group Leader of the Posttranscriptional Regulation of Metabolic Diseases Group

Cristina M. Ramírez received her B.S. in Biology in 2001, and her PhD from the University of La Laguna in 2007. In 2010, after a first postdoctoral period at ULPGC, she was recruited by Dr. Carlos Fernández at NYU to study post-transcriptional regulators of lipid and glucose metabolism. She continued her work at Yale where she was appointed to the rank of faculty as an Associate Research Scientist. In 2015, she was awarded the prestigious “AHA´s Scientific Development Grant” and the “AHA-James and Donna Dickenson-Sublett Award for the Advancement of Cardiovascular Research” special award. Dr. Ramírez´s main research has been focus on the characterization of posttranscriptional regulators of ABCA1, and their implication in Atherosclerosis and Alzheimer´s Disease. She has authored more than 40 publications including book chapters, reviews and peer reviewed articles published in top journals such as Circulation Research, Cell Reports, Mol Cell Biol, ATVB, PNAS, Diabetes and Nat Med, among others. Currently, Dr. Cristina Ramírez is a “TALENTO Program” Fellow and leads the group of posttranscriptional regulation of metabolic diseases which a primarily focus on better understanding and deciphering novel molecular mechanisms and potential therapeutic opportunities to treat age-associated pathologies.

Email: cristina.ramirez@imdea.org 
Phone: +34 91 727 81 00, ext. 312

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